My wife is in manufacturing and although not in US, working for a company having production in US, EU, Asia etc. Her 1-minute comments why it's increasingly difficult to produce something in EU and US.

Bureaucracy - the levels of it are insane especially in EU, but US is not far behind. The loss of local partners and environment - every little thing you can do locally makes production easier and cheaper. Failure to attract young people – although production is cool, it's not Youtube influencer level cool and industry relies increasingly on older generations. Education - the quality of it is sinking almost all over the world. Insecurity - partly just part of times, but mostly coming from regulation, taxes etc.