alt Hacker News> ... This is just a list of someone's ideas for equivalently difficult (and transformative) unsolved problems in biology. ...
I think GP was saying the proof of the pudding is in the tasting: the longer a problem has provably resisted resolution the more difficult it is considered...
bombastically decorating a problem as equivalently difficult does not make it so.
Well, if LLMs actually turn out to solve some of the Millennium problems, at least some of these biology problems are almost certainly at least as difficult. Certainly solving any of them would be Nobel-worthy if biology nobels existed (and solving some of them would likely easily be worthy of a medicine Nobel). It's not like these are new problems whose difficulty is unknown!