As a human who sometimes needs to use the restroom, I like my transit rides to take a predictable amount of time.
Sunset on the Bay Bridge is prime rush hour traffic time, and the favorite pasttime of many Bay Area drivers is to get in a traffic accident after work.
As far as I can tell, these double decker buses are not equipped with a restroom for their riders. Even though I'm sure the view is amazing, the red line is less often obstructed by traffic.
Clean, comfortable restrooms on buses are possible. There just has to be the will to do it.
Every person alive has had to use the restroom. What you mean is that you have a bladder issue.
West Oakland to Embarcadero is great: 7min BART, or 45-60(+) at rush hour on the bridge. No better timesave that I know of with BART.