Nukes. Early tests carried out without absolute confidence of what would set out apocalyptic chain reaction.
Could argue we knew it was dangerous, but pursued it anyway. Could argue it's not much different than now: Unknown unknowns, potentially apocalyptic consequences, hopefully not.
I did consider that, but beyond the yield ignorance factor, we still had to arm them, right? We had to load the fissile and explosive material and assemble the bombs, and we had to trigger them directly, didn't we?