The 'sequel' that does lean on some of Reamde's worldbuilding, 'Fall; or, Dodge in Hell' is much more oddly ambitious. But it is a very strange work. You have to be on board for the literary direction.
It's also concerningly prescient, as he often has been, especially in an early scenario in the book that shapes the world so the rest of the book can happen.
"Remember Moab" has become a sort of in-joke/shibboleth/curse for my close friend group as a reaction to (or identification of) the sort of FB/Instagram things that make real, normal people lose their minds forever.