Assuming you have those under control, what about sustained stress? Little sleep, etc...
Chronic low-grade inflammation is the link between obesity and cancer incidence, so yes, those are not good. Better to be fat and chill (and active) than thin and stressed-out.
On sleep I'm not actually sure if they've parsed out whether it's little sleep itself that affects you or if it's little sleep making you not exercise or eat well
I'm wayyyy less likely to exercise if I've only slept 5 hours