alt Hacker NewsIs VDJ recombination based on viruses or transposons?
It's the first time I hear this. Can't yet say much about it until I can verify that.
Is VDJ recombination based on viruses or transposons?
It's the first time I hear this. Can't yet say much about it until I can verify that.
Yes, the RAG transposon inserted itself into a variable domain exon about 500 million years ago. Here’s a more recent paper on this:
Origin of immunoglobulins and T cell receptors: A candidate gene for invasion by the RAG transposon
https://pubmed.ncbi.nlm.nih.gov/40614193/
> It's the first time I hear this. Can't yet say much about it until I can verify that.
How are you going to verify it?