On AI, I have two goals. First, I want Pyxel's simple API to make programming and game creation enjoyable for people writing code themselves, without AI.
On the other hand, I also think its simple, focused design makes it a useful library for AI-assisted development, including vibe coding. I've published Pyxel MCP (https://github.com/kitao/pyxel-mcp) and Pyxel Skill (https://github.com/kitao/pyxel-skill) to support that use.
Compared with Pygame, which is more general-purpose, Pyxel deliberately narrows its scope and specifications. It also includes pixel art, tilemap, sound, and music editors. The focus is on helping beginners start making games without having to make lots of decisions about tools and low-level details. Those retro, old-school constraints also appeal to experienced game developers.