If you're writing for VM and don't need stuff like GPUs, you can.
For actual real hardware, not really
GPUs, wifi, power/thermal management, firmware. Especially in portable computing there is still a huge amount of hardware support surface area to contend with.
alt Hacker News
GPUs, wifi, power/thermal management, firmware. Especially in portable computing there is still a huge amount of hardware support surface area to contend with.