Welcome to nihilism, where nothing matters. On a grand enough scale, is there a difference between our universe existing and our universe not existing?
Nope. Nothing will last. Everything is chance. Entropy will eat us all.
That's why it's important to find joy in the moment and ways to share that joy and happiness with those around you.
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On a cosmic scale independent of human activity, sure. But things do matter to us every day. And things matter to other life forms we share the planet with.