Personally no. I've been reading a lot on LCD screens (PDAs if you know what those were), way back before eInk existed.

First, eInk used to be glossy, and not backlit which sucked, since you needed a light source to illuminate it well enough, but not so much that it shone on the screen and caused weird reflections.

After they added backlight, it became much better, but I'm not sure how it's better than an LCD (I dont think it is).

The only thing that sucks both about the iPad and most ereaders is the lack of physical buttons to flip pages, which makes 1 handed operation clumsy at best.