OpenBSD was used under NDA's in some really sensitive corpos with Gnome2 setups and some RDP/Citrix clients and even Perl?+GTK2 wireless graphical assisatnt.

https://www.mtier.org/solutions/consulting/

If OpenBSD had a stable GeFS setup as a filesystem -still WIP- (and toad/hotplugd for external FS' mounting) it could get customers in no time, because today except for CUDA the rest can virtually work 100% the same as any Linux distro.