In the book - is it men vs machines? Because it’s pretty clear in our world it will be men+machines vs men(probably also + some machines)
Yeah, basically.
the immediate cause of the Jihad is the abortion of the healthy fetus of a Bene Gesserit, Jehanne Butler, by an AI."
The book starts out thousands of years after it's all over... but later books (prequels) get into into it for us die-hard followers of the series.