Interesting to see this on HN! I've been beating the drum for quite a while that the Butlerian Jihad was never about terminator-style robot uprisings, but rather the intentionally-unexamined half of the themes the Dune ~trilogy ended up being about: long term fate of the species, the prospect of human speciation, the role of cold reason (read: aggressive utilitarianism) in leadership, and above all the concentration of power in light of modern technology.
All he mentioned explicitly was the very last clause, but the others are more important & uniquely-Dunean IMHO, and are central to the plot from the jump through the Bene Gesserit, the Mentats, and the Guild Navigators, all ostensibly Homo sapiens sapiens despite being completely unnatural. Even "Imperial Conditioning" --which obviously plays the biggest part in the first act of the first book-- is arguably the same topic. By refusing to include computers and robots at all, the reader is naturally guided to consider those more familiar tropes in light of the world-building snippets we get. Which is kinda what makes Dune so genius, I think!
Like, to make it explicit... I think having the aforementioned abhumans drive the plot without significant support from inhuman minds raises more subtle questions than we're used to in far-future tales of robots, like:
1. Can one lose their humanity through experience, be it intentional "conditioning" or just the acquisition of power? (see: Paul vis-a-vis Eichmann in Jerusalem)
2. Once one has lost their humanity superficially, can it be brought back/up/forward? Is love/greif the most plausible path, and thus the most human cognitive processes? (see: Dr. Yueh vis-a-vis Eichmann in Jerusalem)
3. If we try to maintain our humanity in the long term --the default goal of non-insane futurists, though debated in the 21st c.[1][2]-- how do we protect against the natural urge to pursue power, which is (arguably) inherently human?[3]
I'll cut it off there cause this threat will likely be deleted anyway and I'm heavily procrastinating. Long story short: the Butlerian Jihad is not a condemnation of artificial minds, and if even it were, the condemnation would apply equally as much if not more so to the humanist empire in which the story is set.
Also, hopefully obvious, but just in case: it likely began as an excuse to write the stories that he wanted to write, just like the shield thing giving an excuse for swords in space. But I think Herbert deserves credit for what was running underneath that and elaborated on as it became a series of novels rather than cute periodical stories. He was pretty smart!
Also also: we do not discuss the son's book about Butler lol. It is verboten.
[1]: https://en.wikipedia.org/wiki/He_Jiankui_affair
[2]: https://en.wikipedia.org/wiki/How_We_Became_Posthuman
[3]: This kind of structural conflict could be described as 'internal contradiction' https://en.wikipedia.org/wiki/Dialectical_materialism or 'endogenous contradiction' https://en.wikipedia.org/wiki/Endogeneity_(econometrics) depending on your preferred flavor of economics.