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meowface • today at 12:45 PM • 4 replies • view on HN

It should be a tiered system, IMO.

1) Where possible, don't test in animals.

2) When testing in animals, first ensure that there is reasonable confidence the risk and severity of harm from the testing will be minimal. Only begin initial in vivo testing after this has first been achieved.

3) For test animals that are or aren't harmed, allow them to live happy, (relatively) normal, natural lives. Don't end their life early unnecessarily, with exceptions for humane euthanasia if the testing has unexpectedly caused significant, persistent suffering. Treat them as a pet owner would treat their beloved pet rat.

Some may consider it extreme, but, in my view, in an ideal world, people would treat testing in animals almost like testing in humans. The researcher should first ask "would I feel comfortable testing this in a voluntary human test subject?" Non-human animals would still be the first line of testing, since harm/death in a rat/mouse/chimpanzee is less morally bad than in a human, but I think this should be the mindset.


Replies

suncemoje • today at 3:10 PM

> It should be a tiered system, IMO.

It is a tiered system, at least if you look at big pharma. There are many stages in the pharmaceutical drug development process.

Also human testing (clinical trials) have different stages/tiers to maximize learning and minimize risk at every stage. A lot of companies trying to innovate here.

I’m exited what more AI can bring to this space.

Palomides • today at 3:36 PM

this is already what they do, you have to justify usage of animals and meet standards for quality of life to do any research at a real institution

also animal research is a huge pain in the ass, nobody is doing it unless they have to

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voidUpdate • today at 2:25 PM

I do feel bad for medical mice, especially things like SCID Mice https://en.wikipedia.org/wiki/Severe_combined_immunodeficien..., which are basically only born to be infected with something, and then die. Even more so in a recent case of academic fraud I've seen involving cancer testing, where the data was obviously faked, but mice still died for the data.

But yes, it's hard to test immune responses without hurting a living animal, since you'd have to somehow have a non-alive immune system to test on otherwise

sporedro • today at 1:08 PM

I agree. If it’s a question of just cost - (animals being cheaper to just test on quickly and faster) animal testing shouldn’t be allowed.

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