alt Hacker NewsN of 1, but I had serious low drive/motivation side effects from Wegovy. Everything enjoyable became less enjoyable, from alcohol, to running, and after a couple of months, even getting out of bed. I lost weight slower than I had previously with old school calorie counting (most of which I have kept off to this day). Within a couple weeks of getting off it I was back to normal.
My conspiracy theory is that a lot of people must be getting this global lowered reward sensitivity from GLP-1s but are ignoring the negative sides of that effect because they like being skinny.
> My conspiracy theory is that a lot of people must be getting this global lowered reward sensitivity from GLP-1s but are ignoring the negative sides of that effect because they like being skinny.
Possibly some of them could also be unintentionally countering the impacts through things like self-medicating with caffeine.
I have no personal experience with GLP-1s but suddenly quitting caffeine after decades of daily use was pretty eye-opening in terms of how much it was boosting my baseline mood. And I'm not talking about being cranky for a couple of days after quitting, I'm talking about a very noticeable sustained change from when I was a frequent caffeine user to when I stopped having it altogether.