Symbolasm looks interesting. Without having tried it, the first thing that comes to my mind is that it would be a bit more complex for debugging, because you are using two different representations to do the same thing (one for writing code, one for reading it back). Not sure if this is an issue in practice.

Of course, the same issue exist in any compile language, say C, but you don’t expect to see C in a disassembly. Here you are working at the assembly level.