As an example I run opencode and anything related agent-related in its own dedicated KVM VM with its own LVM logical volumes for storage on a headless server. This has no access whatsoever to the personal data that lives on my laptop and workstation desktop PC. The VM gets periodically imaged and backed up, and is relatively easy to move between host machines if I need to.

One benefit of doing this is that I can leave it doing long term slow things with slow but capable LLMs on a truly 24x7 basis without worrying about it being interrupted by a laptop being closed/going to sleep, or workstation level software updates/reboots on my primary desktop PC.