Maybe a materialist biological exceptionalism position could be that biological substrates are capable of sending kinds of signals that silicon substrates are not, in the sense that brain matter especially might give rise to far greater complex processing in ways that we don't know about or appreciate yet, and which we may discover can't be efficiently recreated in silicon?
I don't know if I buy that argument or even if it makes sense. But yeah this all smacks inextricably of soul talk.
I agree that as per current understanding, the functional biological base units have more degrees of freedom and a greater functional diversity as a result, but that’s merely a quantitative difference not a fundamental distinction. One could imagine equally more complex silicon base units beyond what we have now. Whether they need to follow the same pattern/modes as the biological units remains to be seen (but it’s pretty hard to argue against evolution as an efficiency maximiser).