> When you start adding variables to the search space (emi interference, matching routing impedances, heat management, mechanical integrity, etc) the search space grows so big that any non-expert will become lost in it.

Have you tried Astra?

I'm designing an analog ASIC. It will suggest e.g. transistor matching. You can also give it hints for layout.

You still need to validate with SPICE simulation (and obviously silicon).

I'm also looking into non-LLM scripts that use brute force aided by heuristics (e.g. lookup tables) to efficiently search the solution space.