Gonna dump a technical hot take here.
Python is a mature production language with a lot of users. Even before it was huge - like 20 years ago when I was in college - getting a small backwards compatible API change into a python extension module (gnu readline in my case) required convincing GvR personally that the API change was necessary.
Every JIT attempt I've seen for python just tries to cut too deep in the first pass, and scope themselves too large.
I believe any successful attempt at optimizing python performance from JIT will FIRST start with a 100% semantically compatible hidden type model for optimizing object property access and method dispatch.
The single biggest performance delta in most dynamic language jits come from that, not from optimizing guards off of bytecode operations or from compiling to machine code. It's from converting hashtable lookups into constant-time guard + offset lookups.
The hidden type model is also a hard nut to crack. It needs to perserve dict semantics which have very dynamic behaviour via the various `__*__` methods, and handle exotics scope objects since scoped name lookups are the most common ones which have their own exotic behaviours (I remember python providing some ability for callee frames to inspect caller scopes in some limited ways).
It still blows my mind that the big "we're breaking backwards compatibility Python 3000" release didn't do anything to lay the groundwork for this, or any of Python's other structural problems.
> It's from converting hashtable lookups into constant-time guard + offset lookups.
Python already does it in a lot of cases, see opcode specializations like LOAD_ATTR_INSTANCE_VALUE, LOAD_ATTR_SLOT.