Coming from an environment in which we extensively use mixed codebases (C++ and Python) to combine performance and ease of prototyping, one of the pain points is that there is almost always some impedance mismatch between the lifetime/ownership models of the two languages. When something goes wrong here, it's usually a real pain to debug and resolve, and often the resolution involves imposing constraints from one language onto the other (e.g. C++ that would idiomatically use unique_ptr instead needs to use shared_ptr because unique_ptr is essentially impossible to completely capture in Python).

Given the issues involved in mixing languages, there can be cases where sticking with one "good enough" GC'd language and having to write a few performance-sensitive parts in very unidiomatic form to minimize/eliminate GC work is preferable.