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Ozempic-style drugs now in trials for heart failure, addiction and even aging

39 points • by randycupertino • yesterday at 3:24 PM • 11 comments • view on HN

Comments

deskamess • yesterday at 11:45 PM

For those who may have tried other variants... is there a big difference between Ozempic/Wegovy/Mounjaro? My doctor prescribed WeGovy but my insurance does not cover it - my spouses does. However Mounjaro is covered by both insurances. Is it worth (effectiveness) switching to Mounjaro? I heard it is a 'double agonist' - what exactly does that mean?

I am also reading up on things called triple agonist but its not readily available in Canada. Web sites with a lot of discussion about peptides and titrating which seems a little difficult.

gib444 • yesterday at 9:58 PM

It totally solved my food addiction. It flipped it like a switch - I knew what most people are like, where food isn't a thought every 15 minutes. What a glorious time. So much free head space

It is now firmly back, after ~6 months off the drug (due to cost) :/

I've managed to keep off the lost weight, through a lot of willpower, but winter will be a struggle I can tell.

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perching_aix • yesterday at 10:51 PM

If a molecule can downregulate (downmodulate?) cravings so effectively, could there be a molecule that does the opposite?

This is basically about as far as I feel like entertaining conspiracy theories. I think it's a fairly grounded one, compared to most.

Not claiming that a molecule or a class of such molecules (or a perfect storm of unrelated molecules acting indirectly) is behind the obesity epidemic, or that there's explicit malicious intention involved, just that it does make me wonder.

arjie • yesterday at 9:40 PM

These drugs are a godsend for so many (me included, on retatrutide) but especially for those of us here in America - legal environment broad enough to get them, relatively wealthy enough to afford them, and notably fat enough to benefit from them. The diffusion of this technology through the US might well increase American lifespan in a notable way.

Now all we need is an easy pill that makes you hate opioids.