I occasionally drive 300 miles in an EV rated for ~319 miles, and I have to stop once in each direction, but I also have to charge at my destination. There's a Tesla station near there, and the rates are fantastic if you get there before 7 AM.

I keep it at 65 and let the heater do whatever it wants to do so that people are comfortable. Temperature, elevation differences, and wind definitely change things.

There's a section of the drive where I average something like 1.3 mi/kWh on the way up the mountain, but something like 6 mi/kWh on the way down. On the return trip, it's kind of fun to see the guess-o-meter show 110 miles remaining over the course of 25 miles, or have it actually increase.

I'm sure that gas vehicles follow a similar pattern, but I don't pay attention to usage like I do in an EV.