alt Hacker News> If DNA has everything encoded
It is not. There are many biological examples of random processes generating patterns and weights, such tiger stripes, fingerprints, etc. DNA only encodes the reaction, but the pattern itself is seeded by initial position of random molecules, not the DNA.
> that it influences the initial state of the brain.
You've gone from "DNA is probably the seed for the random initialization", as in the deterministic seed for a PRNG, to "influences". Those are 2 different claims.
Most scientists will agree that DNA encodes the large-scale connectivity in the brain, ie from region to region, thickness of corpus callosum etc.
Most scientists will disagree that it is "probable" that DNA encodes/seeds the weights of each and every synapse.
I think you are mostly debating against a strawman of your own construction here. The person you're responding to never claimed that "seeding the random initialization" means literally the same thing as seeding a pseudo-random number generator, and the second message was likely intended as a clarification after being misunderstood. So it's not "2 different claims" contradicting; it's a single underlying claim being expressed through a lossy medium in an increasing level of detail.
My own reading of the poster's intent aligns with this: "DNA encodes the large-scale connectivity in the brain, ie from region to region, thickness of corpus callosum etc."