I'm a right-handed player and missed a bunch and then I quit. I wondered if maybe I somehow set it to an alternate tuning or something? Went back and realized they have the strings listed in the opposite order that I expected (my guitar has the low E on the top and the high E on the bottom).

hi there...assuming you're talking about the game itself, it has a left handed mode under Settings [Under dropdown you get when you click/tap the profile icon on top right)