These kind of things should be fun to test in Coreboot. When Dasharo was released for the MSI PRO Z690-A DDR4 more than four years ago, I had issues with two Radeon 5600XT installed that was fixed after developer tuned some MMIO related parameters: https://github.com/Dasharo/dasharo-issues/issues/245 How many PCIe Switches you could chain and how many cards with absurd MMIO requeriments you can get working would be an interesing experiment.

In the last decade or so I have seen plenty of Firmware MMIO related issues. I remember certain SR-IOV supporting NICs (Usually Intel ones like i350 and other enterprise parts) not being able to reserve enough MMIO to create all the supported SR-IOV Virtual Functions in consumer Motherboards, in many cases you could get SR-IOV working but were limited to create like 4 VFs even if hardware supported 16 because that is what you could fit. This was essentially all a Firmware issue, not Hardware, but few people has the required skills to do any BIOS modding to fix rather convoluted things like MMIO allocation. Basically, you're trying to workaround Firmware issues elsewhere.