David Friedberg recently did an All-In Interview with the CEO of Eli Lilly. Interesting conversation over there that also talked about some key points of the article.
WFH & being sedentary
Since WFH, it’s scary to me how sedentary I have become.
It wouldn’t surprise me if I now walk < 1,000 steps per day.
I can easily go a couple of days and never even leave the house.
My waistline shows it. And I’m actually eating less than I did when I went into office.
I guess its basic thermodynamics.
Well the title is a little silly even if it's meant to be provocative. There's a limit to just how many people would benefit from the drug, since those who exercise frequently enough wouldn't have the need for it ever.
Let’s all go on it, and steroids
It's a pretty sad thought that everybody will be on a drug that keeps weight in check while most people will still eat a basically toxic diet. Weight is certainly an important factor but there is more to a healthy life.
How are the side effects?
I read plastic surgeons said it was bad for your skin and people would look much older when they take it for a few months.
Yet, I also read it was generally good for your health, not just in terms of weight loss.
The absurdity of creating a drug to curb obesity instead of forcing industrials to make food healthier. The ravage of corruption, sorry lobbying, still killing us all for greed.
for those that do not know there is a herb that targets GLP-1...its called Berberine
And yes its over the counter....I currently take one dose per day at 1200mg
Who has time to eat? Founder mode all day every day.
My friend and my father in law both went on it. They both became suicidal and had to stop. YMMV but that’s enough for me.
Eat less. Move more.
The real fun will be when there is enough of this chemical in our waste runoff that cattle and wildlife gives up eating
Not a surprised that in the land of the obese (mostly by choice), weight loss poison is deemed a miracle drug
Okay, how I found out about berberine being over the counter...this medical article and study
https://pubmed.ncbi.nlm.nih.gov/34981502/
Imagine only spending $11 with no side effects to spending $300 and up with major side effects.....
I long for something that would help me. I have a rare metabolic disorder where the recommendation is high carbohydrates, very high, and to never diet. Even a ten percent reduction in caloric intake can end in hospitalization, during which I am put on a frankly enormous amount of glucose or sucrose, among other things. The end result has been an insidious weight gain. Exercise? Well, aside from the fact that you can't outrun your fork, it sets off the same metabolic pathways that caloric restriction does and I am back to square one.
Are we all diabetic? Because that's why I'm on it.
I’m just as curious as to why some people are so willing to take numerous medications, while others go to any lengths to avoid them. Some people are happy to be on an SSRI, sleeping pill, statin, low dose aspirin, and a few others, and aren’t bothered by this. Other people seem instinctively revolted by prescription drugs, seeing toxins pushed by evil corporations. Is it a trust issue?
I personally detest and avoid all medicines other than antibiotics and vaccines. Pharmaceuticals have a long track record of harboring “side effects” that only become apparent years later.
In general, why are we surprised that the chronic use of any substance has negative effects? Humans evolved for thousands of years eating food and drinking water. Regularly consuming anything else is an abberration and self-experiment.
Eternity, unless it's pumped into the water supply
For a second I thought it said Asterix Mag and started daydreaming about a story where Getafix invents a special magic potion which Obelix can use but it causes him to lose weight. Dargaud, I am available.
Why can’t there be a drug for chronically underweight
I think there will be a time when engineered chemicals will beat natural food, but right now this isn’t it. I’m talking about longetivity tech in the far/ or near future
The American Academy of Pediatrics suggests starting children on weight loss medication as early as 12 years old:
https://publications.aap.org/pediatrics/article/151/2/e20220...
The farmers are subsidized to grow the corn. 10% of SNAP benefits are spent on sugary drinks. Yet we're expected to believe that these children were born w/ the chronic disease of obesity and they'll need to be on these drugs their whole lives.
Love this forecasting methodology
The day Ozempic/similar drugs become approved for weight loss under ACA/Medicare is the day I stop paying taxes.
Fuck that. Just have some willpower! Some of us have been doing OMAD without assistance, just grunting through the stress and pain for years. It's much healthier than drugging up.
Can you keep the weight off once you stop using it? I don't particularly want to have my personal health be in the hands of one company especially if the culture stratifies into those who can afford to be the right weight and those that can't. Especially when it enters it's "enshittification" stage.
Seems to me this drug is an antidote for an unregulated capitalist system creating an environment that preys on the human condition and as a result makes people unhealthy.
It's just now selling you the antidote to the problems it made. Profit.
HN must be aging.
The number of 'smart' people in this thread advocating for the use of a drug instead of doing the obvious which is STOP EATING JUNK FOOD is staggering. Also the article is nothing more than a pharma ad. Idiotic and corrupt.
We were having the same discussion 5-10 years ago about Metformin. Just saying
Yet another drug that patches up symptoms without addressing the root cause. People will be dependent on the drug for life. And we still don't know what the adverse effects are.
Drugs rule.
gonna be a good while
Uhhhhh, Ozempic has so many problems and side effects that get glossed over.
Maybe when food shortages become a thing, we can add Ozempic to the water supply to curb people’s appetites and reduce demand. \s
Kidding aside, I still think it’s extreme for off-label usage. Short term results are nice. But what about the long term? Once patients reach a desirable state, can they be titrated off the medication while maintaining their ideal labs and weight? What’s the rate of recidivism?
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just eat healthy and be active
So basically eat shit and then take drugs to lose the weight you accumulated because of your bad diet ??
Am I the only one to realize how this is so wrong?
You would think When a pipe leaks, you fix it. You're not going to put a basin under it, empty it every day, pay for a new basin every few week and continue to have your damn pipe leak.
Oh man... If only you could teach people how to eat better instead.
Why would you ever take a pill for weight loss?
That’s seems entirely fucked up
I'm old enough to remember when "weight loss pills" was a cliche punch line. Thank God there's no way these miracle drugs will turn out to have some terrible long-term side effects!
FWIW, I was prescribed a GLP-1, but my insurance will not cover it. It's incredibly expensive out of pocket.