alt Hacker NewsDoes anyone have references on any explanation, or even partial explanation, on why this might be the case?
The published stuff I can find seems to be at the level of anecdata, scarcely better than "I know a guy who..."
- What people talk about on social media: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669484/
- Some people made large "reckless" life choices: https://academic.oup.com/qjmed/advance-article-abstract/doi/...
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> Does anyone have references on any explanation, or even partial explanation, on why this might be the case?
Not yet. The effect appears to be real, but it's too soon to tell: https://www.science.org/content/blog-post/ozempic-and-other-...
From my own anecdata, unnecessary impulsive eating probably reinforces the impulsive behavior. You start associating impulsive behavior with a reward.
GLP-1 not only removes that, but adds a slight negative reinforcement. Impulsive eating no longer brings reward, but makes you feel over-full. This can then down-regulates the pathways that lead to increased impulsive behavior.
There are about a dozen published studies using GLP-1 analogues in animal models showing reduction in addictive behaviors (search for papers by Jerlhag, Leggio and Schmidt). The prevailing theory seems to relate to dopamine regulation.