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fourside10/11/20242 repliesview on HN

I’m skeptical of the idea that across the general population we’d be healthier if we dialed up our insulin production. Serious question but has there ever been a case of humans benefitting from increasing a hormone like this? Since it’s an injection, It wouldn’t be a steady increase, but more likely have bursts of it. I don’t know how healthy that would be in the long run.

After what happened with OxyContin I think wed benefit from some skepticism when a new drug gets oversold.


Replies

pixl9710/11/2024

> Serious question but has there ever been a case of humans benefitting from increasing a hormone like this?

By itself this might be an ok question, but in context it's rather useless....

Diet and obesity changes by both lowering and increasing different hormone outputs in your body. You're balancing the question of "how is this hormone" versus "How bad is obesity on the body". Well, the answer is in, obesity is extremely unhealthy on the body in both the short and long term.

Drug overdoses cause somewhere around 100k deaths per year in the US. Obesity complications related deaths are in the 250-300k deaths per year.

You can be skeptical as you want, but behind smoking, obesity is the worst epidemic in the US.

aantix10/11/2024

GLP-1's have been around since 2005. Exenatide.

They're not new.