alt Hacker News> Someone I know took about 4g of MDMA over a 4-day period
For anyone reading who's unfamiliar, this is a ridiculous dose of MDMA. A normal recreational dose would be 0.1g-0.2g once every few months. (I have no idea whether this dose is safe or not, just saying it's a common one for people to take.)
A bad thing about MDMA is that you become tolerant to it very quickly, so people who do it too regularly need to take more and more over time to feel the effects. That's probably what happened to the parent comment's friend.
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I've seen someone do 1g over the course of a long evening but they were a seasoned user. That's the kind of dose that would send a average sized teenage girl to a hospital in convulsions. 4g over 4 days? It's not even about the tolerance at that point, by days 3/4 do you even have any serotonin left for it to be any fun?
I'd argue 100 to 200mg every few months is a normal therapeutic dose.
What's normal and recreational is much less well defined.
Having experienced this exact dosage, I can attest it is more of just raw dragon-chasing juxtaposed with an insane tolerance curve.
The euphoria caused by MDMA combined with literally any other drug (MDMA is like ketchup, can be combined with anything) synergizes and can quickly escalate to rampant re-dosing that _exponentially_ increases tolerance, all while preventing the receptor to re-regulate.
The "sads" following MDMA binges are so ironically over-bearing to a point of near artificial-ness and it is nearly obviously attributable to the chemical.
MDPM/6-APB are interesting as they are euphoric and serotonic but with less manic depressive the next circadian cycle.