alt Hacker NewsTying this to APOE, specifically e4 which has an increased requirement for choline and when choline levels are low there can be a metabolic push that leads to elevated PHGDH activity and consequently, increased serine synthesis. That is a neat connection and maybe why when we study choline supplements we see positive results.
https://www.sciencedirect.com/science/article/pii/S000291652...
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xlbuttplug2 • 04/28/2025
> In conclusion, our findings suggest that moderate dietary choline intake, ranging from 332.89 mg/d to 353.93 mg/d, is associated with lower odds of dementia and better cognitive performance.
Gemini tells me that amounts to ~850mg of alpha GPC or ~1900mg of citicoline. Eggs it is then.
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j45 • 04/28/2025
wow, thanks for sharing.
That is super interesting, as is the relationship between choline and sleep. With restorative sleep function, and specifically slow-wave activity, considered to be a significant driver of AD.
https://www.jarlife.net/3844-choline-sleep-disturbances-and-...