WINE has basically become a gaming wrapper at this point. There are not many (modern) apps outside of games that run on WINE. However, games run great!
Last I checked, Office 365 didn't work, Basically anything modern Adobe didn't work, even the latest version of Visual Studio (not VSCode) didn't work. Things may have changed, I just learned to live without that stuff.
That's because all those apps are purposefully hostile and actively do everything in their power to make sure they don't work without their authorization.
Solution: don't use those apps and maybe people will learn. Eventually, apps and technologies like this die in our digital landscape. Rest in piece Flash, you will be missed. 3D max and Photoshop, you're next.
Real solution (for now): just don't give these assholes money. If you need to run the software, fine, but at least have the decency to steal it.
A niche Wine does suit well is running audio plugins for music production.
Wouldn't have believed it if I didn't first see and then use it myself.
Think it's because JUCE is relatively well-supported on Wine and natively on Linux, there are hardly any dependencies outside of system libraries and a DSP library.