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DrierCycletoday at 4:18 PM4 repliesview on HN

AlphaFold is optimization, not thinking. Propaganda 'r us.


Replies

fredoliveiratoday at 4:27 PM

Did you watch the documentary? Would probably fare better if you did, because it'd give you the context for the film title.

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Rochustoday at 6:16 PM

Not sure why this is downvoted. The comment cuts to the core of the "Intelligence vs. Curve-Fitting" debate. From my humble perspective as a PhD in the molecular biology /biophysics field you are fundamentally correct: AlphaFold is optimization (curve-fitting), not thinking. But calling it "propaganda" might be a slight oversimplification of why that optimization is useful. If you ask AlphaFold to predict a protein that violates the laws of physics (e.g. a designed sequence with impossible steric clashes), it will sometimes still confidently predict a folded structure because it is optimizing for "looking like a protein", not for "obeying physics". The "Propaganda" label likely comes from DeepMind's marketing, which uses words like "Solved"; instead, DeepMind found a way to bypass the protein folding problem.

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dwa3592today at 4:24 PM

what is thinking?

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