alt Hacker NewsAnisotropic mouse movement?
Or perhaps the 0ms-80ms distribution of mouse movement matches the >80ms mouse movement distribution within some bounds. I'm thinking KL divergence between the two.
The Kolmogorov-Smirnov Test for two-dimensional data?
There's a lot of interesting possible approaches that can be tuned for arbitrary sensitivity and specificity.
Like another commentor mentioned, I think that only works for a specific cheat(engine) - as long as they don't adjust (and randomize more for example). If it could be solved with some statistics, I think it would have been done already. I ain't a statistician though, but if you feel confident, I think there is quite some money in it, if you find a real world solution.