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matthewdgreenyesterday at 6:44 PM5 repliesview on HN

I looked into a chickenpox vaccine a while back, but it turns out the current varicella vaccine uses a live virus. So if you're fortunate enough not to have been exposed to chickenpox, taking the vaccine could put it into your body. The Shingles vaccine, on the other hand, has no live virus at all. But you can't get that til 50.

ETA: Since someone downvoted this: I'm not criticizing vaccination, and you should absolutely get your kids vaccinated! But for someone (like me) at the age where you've seen friends with Shingles (ugh), adding live chickenpox virus to your body feels like a risky idea, even before this news.


Replies

amlutoyesterday at 7:05 PM

We will start finding out whether people who got the varicella vaccine instead of chicken pox get shingles at a similar rate soon — the older members of this population are approaching shingles age.

Here’s a study that looks good:

https://academic.oup.com/jid/article/226/Supplement_4/S470/6...

The headline conclusion is:

> Latent VZV can be wild-type VZV (wt-VZV) from natural infection, vaccine-strain VZV (vs-VZV) from immunization with live attenuated vaccine, or both. Based on available data in children and adolescents, the risk of HZ from vs-VZV appears to be approximately 80% lower than the risk from wt-VZV, with a lower incidence found in 2-dose as compared to 1-dose vaccine recipients [9, 10].

A major caveat is that the relevant age groups were very much too young for shingles vaccines at the time the study was published.

mickdarlingyesterday at 7:43 PM

The age gating of needing to be 50 years old to get the shingles vaccine is really obnoxious. I had shingles outbreaks twice in my life, one in my early 30's and once at 48. Obviously, both before 50 years old.

I had to argue with my doctor to prescribe the Shingles vaccine at 49. And when I had it in my 30s, nobody even bothered to give me any antivirals, which did exist at the time, or nerve pain relief.

After I had the shingles vaccine, nerve pain that I'd been suffering with every time I got the slightest little allergy or cold suddenly disappeared, and I haven't had it since more than a year later.

If you are under 50 years old, and had chickenpox, and especially if you've had one outbreak of shingles, force your doctors to prescribe the vaccine. It costs $100-$200 without insurance coverage, and it is worth it.

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ikrenjiyesterday at 7:48 PM

I don't understand this kind of reasoning. You don't think that the 100s of PhDs that worked on this would have accounted for the riskiness of adding a live chickenpox virus vs not adding it? People need to start trusting experts more and do less of "common sense" over-thinking imo.

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triceratopsyesterday at 7:02 PM

> But you can't get [the shingles vaccine] til 50

This is inaccurate. I know several people who got it younger than that after contracting shingles and recovering.

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wesleywtyesterday at 6:53 PM

Its an attenuated vaccine, which means it was grown to be weaker then the wildtype by growing it in non-human cells making it more specific to what it was grown in. I have never had chickenpox because i had the vaccine. If had chickenpox as a child you were extremely unlucky because its completely unnecessary.

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