If you're relying on a trusted gateway, you don't need any of this; just do TLS to the gateway to exchange messages. This is how 95% of corporate "secure email" systems work.
But you don't know how many SMTP relays the recipient has and if they are all secured. E2E encryption, be it via GPG or x.509/SMIME, is still good in that case.
But you don't know how many SMTP relays the recipient has and if they are all secured. E2E encryption, be it via GPG or x.509/SMIME, is still good in that case.
edit: smime