Stanford scientists found a way to regrow cartilage and stop arthritis

https://www.sciencedirect.com/science/article/abs/pii/S01637...

Reduce arthritis, get cancer?

https://www.science.org/doi/10.1126/science.adx6649

A small molecule inhibitor of 15-hydroxy prostaglandin dehydrogenase causes cartilage regeneration. I hope they fast-track it to human trials.

HN posts about mouse studies always trigger a bunch of skepticism. I’m a layperson so it’s hard to separate the informed comments from me-too contrarians.

Are there areas of medicine where mouse models have a much higher or lower success rate in human trials?

Years and years away unfortunately. Many trials and chances for failure on the human side.

It's discouraging to see these on HN and then realize that most never go anywhere, or are so far out you may not see it in your lifetime.

Maybe we should flag anything not already in a phase 3 trial :)

I’ve had my shoulders “cleaned up” arthroscopically, and the pain is still a major preventer of movement. I would love to stay on the mats longer with something that doesn’t harken to medieval times. So excited at this prospect.

Fusion Power

Cartilage Regrowth

Room Temperature Semiconductors

Quantum Computing

    def generate(topic, year):
       return f"Scientists have made a major breakthrough in {topic}"

Of course, why are the good ones always in mice?

  A study led by Stanford Medicine researchers has found that an injection blocking a protein linked to aging can reverse the natural loss of knee cartilage in older mice.

Would this work for rheumatoid arthritis? I don’t know anything about it myself so it could be a completely different thing, but someone I know has it and it is awful. Would be great to see a treatment coming through.

basically every growth process in the body can be induced by chemicals. and so now people are starting to take some of these chemicals. we will see how it turns out

My dream is to be able to run again. Please. Let me run a 10k at least once more in my life. To feel that stillness and freedom and calm that sets in when the brain start going to hibernation after about 7km.

That would be quiet something to feel that again.

As long as regrowth can be controlled. Otherwise we call it cancer. Would be amazing to get a treatment for osteoarthritis.

>Human cartilage samples taken from knee replacement surgeries also responded positively. These samples included both the supportive extracellular matrix of the joint and cartilage-producing chondrocyte cells. When treated, the tissue began forming new, functional cartilage.

Once again, not in humans, in mice. We don't know if the same result happens in humans. At all. We need to proceed to clinical trials to determine if a result is indeed positive.

The discovery of gerozymes is interesting. Maybe aging is pre-programmed after all, to make space for new generations.