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> Construction of an infectious horsepox virus vaccine from chemically synthesized DNA fragments
https://journals.plos.org/plosone/article?id=10.1371/journal...
In theory, it's very much doable. We brought back an extinct cowpox virus a while ago using mail-order DNA. Did you know that Smallpox's nucleotide sequence is freely available online?
It might be possible to reintroduce Smallpox and I guess that idiots who also think coal is a good idea might actually be stupid enough to make it happen. But, fortunately humans did wipe out one other disease and unlike Smallpox it wasn't deemed useful as a biological weapon so AFAIK nobody kept copies, it's just gone.
https://en.wikipedia.org/wiki/Rinderpest