Yes, for all practical purposes. This is the position of physicist Sean Carroll and probably others. We may not know what is happening in the middle of a black hole, or very close to the big bang, but here on Earth we do.
"in the specific regime covering the particles and forces that make up human beings and their environments, we have good reason to think that all of the ingredients and their dynamics are understood to extremely high precision"[0]
ER=EPR says something completely shocking about the nature of the universe. If there is anything to it, we have almost no clue about how it works or what its consequences are.
Sean Carroll's own favorite topics (emergent gravity, and the many worlds interpretation) are also things that we don't have any clue about.
Yes there is stuff we can calculate to very high precision. Being able to calculate it, and understanding it, are not necessarily the same thing.