I successfully did this the other day. There was a web app I used quite a bit with an annoying performance issue (in some cases its graphics code would spin my CPU at 100% constantly, fans full-blast). I asked Claude to fetch the code and fed it a few performance traces I took through Firefox, and it cut through all those obfuscated variables like they weren't even there, easily re-interpreting what each function actually did, finding a plausible root cause and workaround (which worked).

Can you generally trust it to de-obfuscate reliably? No idea. My sample size is 1.