alt Hacker NewsI'm glad we have GLP-1, and I don't think there are really major side effects. But they are ineffective outside clinical trial setting for treating obesity.
It seems to be like treating alcoholism with disulfiram: it's a miracle in clinical trials but in the real world the patients just lower the doses or discontinue treatment after 1-2 years and go back to their old habits.
Replies
> they are ineffective outside clinical trial setting for treating obesity
This is totally false. I know a number of people who took GLP-1 to treat their obesity and then stopped and have stayed not obese.
It is not ineffective outside of clinical trials. All the evidence says that people gain some weight back after they discontinue treatment - which is not a lack of efficacy. But they also usually gain back less then they lost.
> But they are ineffective outside clinical trial setting for treating obesity.
This is one of the wildest claims I have ever seen on this website.
Would you claim insulin is ineffective outside of clinical trials for treating type 1 diabetes because people have to keep injecting it?