PFAS (and, to a lesser extent, plasticizers) circulate from the blood to the gut ~5 times per day through enterohepatic circulation (https://en.wikipedia.org/wiki/Enterohepatic_circulation). This is why cholestyramine was shown to be effective at reducing serum PFAS by up to 60% in a Swedish trial.

Blood donations are also somewhat effective, saunas less so. Also, to be clear, PFAS are very different from microplastics. PFAS are the Teflon chemical.

It's a common misconception, but microplastics and forever-chemicals (PFAS) are not the same thing. They're two similar, but distinct pollutants.

> Are saunas and blood donations not also effective for this?

Yes, plasma & blood donations are good at reducing PFAS blood concentration. Some(?) firefighting foam contains PFAS, so they tend to have high blood concentrations. Donations have shown to significantly reduce that: https://pmc.ncbi.nlm.nih.gov/articles/PMC8994130/

Saunas helping with any kind of detox is complete hocum.

Blood donations clearly do.

Microplastics and PFAS aren't synonyms however.

What isn't established is a dose dependant harm from PFAS. Some things are harmful in minute quantities to the point it doesn't matter if you have a lot or a little.

Lead has a clear dose response but a relatively low threshold for noticeable harm. It's not clear what PFAS curve will look like.

I won't restart the linear no threshold flame wars about radiation harm but let's just say it's not always intuitive.

In PFAS's defense, we really needed to poison the whole planet. Otherwise people would have occasionally needed to get wet in the rain, or perhaps scrub their pots and pans. Really, these extremely minor conveniences are worth the devastating cost to ours and future generations.