I went from a Kinesis Freestyle 2 that I'd used for almost a decade to the Glove 80 with the Glorious Engrammer key layout/functions: (https://sunaku.github.io/moergo-glove80-keyboard.html#layers)
It took a few weeks to get used to, but now that I've got the muscle memory down it's a blast to use. Having function layers makes so much sense once you get used to them. Why use Control + C and Control + V and the hand cortortion it causes on a daily basis when you can hold down the G letter key and then press j/k to copy/paste. The thumb cluster is quite handy as well, I have one button mapped to a custom script that I run dozens of times a day.
I went fro regular keyboard to happy user of (slightly modified) Glorious Engrammer here.
I use qwerty and I'm really not a fast typist, but the "primitives" and thought put on this layout, from home row mods timings, pinch movements, mouse layer, symbol layer etc really helped me to stay comfortable keeping the hands on the keys with less finger movement and less overreaching to the mouse, which really was what was harming my wrist.
The keyboard in itself is great and all, being split and easy to mount creatively also helps for ergonomics, but to me it's half the battle. In fact at the begging, with default and using a mouse in the middle of both halves was hurting my hand even more.