Somewhat relatedly, is there something halfway between QEMU and Unicorn? That is, a full VM in a library, with debugging capabilities. I'd like to be able to configure a VM, save the execution at a specific point, modify memory, run, and stop when some condition is hit (e.g. a memory address is read, or executed). For years I've had this idea of running the Jamella editor in multiple threads to crack Diablo II item seeds.
Well, there's ptrace/gdb? (Since you mentioned Diablo II, you might want a windows debugger, but same idea)
I use Qiling [0] (built on top of Unicorn) sometimes for this kind of things (it can take application snapshots, that you can restore; and you can also use something similar to x86/x86-64 memory hardware breakpoints too). Might fit what you want, although it can sometimes be in a pain in the rear to set up...
[0] https://github.com/qilingframework/qiling