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barakelast Saturday at 11:04 PM3 repliesview on HN

Semaglutide does an incredible job of keeping my autoimmune issues in check. The only side effect I've had is needing to drink more water or else I feel like I've got the flu. Minimal tradeoff IMO


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faangguyindiayesterday at 1:59 AM

I remember reading the Hazada paradox, where they found these Hadza tribe members who live an active life, walking miles, hunting, and doing all physical labour, have the same maintenance calories as a Western person.

So where does the energy burn in a sedentary population come from vs highly active Hadza tribe members?

Pontzer’s research showed that while the Hadza were highly active, they actually demonstrated lower baselines of certain markers of metabolic and physiological stress over time compared to Western populations.

Don't quote me on this; I am paraphrasing things I remember from.

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spbaaryesterday at 1:34 AM

Thirst affects me in a different way too. My throat doesn't feel dry and uncomfortable because before it reaches that point I almost get naseous.

npuntlast Saturday at 11:05 PM

oh say more?

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