Healthy but sedentary people show early decline in cellular energy production

19 subjects, assigned sedentary or active based on habitual physical activity levels. Subjects were screened on basic health measures.

The problem with this is that people are sedentary or active for a variety of health-related reasons that are not captured in any screen (esp. the crude one used in this study). As a predictive study, this is fine, sedentarism predicts a lot of bad things. But it doesn't, on its own, suggest that becoming active is helpful. See also grip strength and mortality.

> mitochondria, which process energy within cells, showed a significantly decreased capacity to burn both sugar and fat in healthy individuals who get less than the recommended 150 minutes of exercise a week.

150 minutes a week is about than 22 minutes a day. Like 11 minutes twice a day. This looks like a really low effort to rid oneself of the risk of early decline.

I abhor exercise for the sake of it. Instead, I refuse to use a car to do anything but bring my family members to distant medical appointments, and the rare carpool'd vacation. Anything within ~ten miles of home I do with human power, sometimes augmented by stored electrical energy (cargo ebike; I contribute ~1/3 the Wattage). Thus, I get plenty of exercise throughout the day. We used to meet our needs by moving our bodies. Understandably, there are perceived benefits to outsourcing transportation, and very real consequences.

Exception is a morning plank to wake up my core, and sometimes forward bends with a weight. I don't like to do it, but I do feel better afterwards (like with cold showers), so I do it. Harder to do with longer exercise routines, which is why I addressed the cause of my unease rather than slapped on plasters.

I'm confused. The study doesn't mention "Zone 2" even once ...

I was busy building a sensorless maintenance calorie tracker. Sometime back i posted this on HN: https://news.ycombinator.com/item?id=48614890 It also has "sedentary" detection which i find pretty useful for the phases when my activity level drops, reduced activity directly reflects in your maintenance calories which maybe useful to some.

Of If I walk 10 km a day on average and do strength trainings 2-3x a week but sit for 10 hours a day - am I sedentary or not?

Exercise is the key to a long healthspan.

I have no idea what 'sedentary' even means. I work on a desk mostly but I also walk 15 - 20 k steps per day because that's just my life and I accomplish most daily tasks (shopping, going to park, coffee, etc walking). Is that sedentary?

Our mitochondria process the total of our energy needs every day, while exercise adds, percentagewise, only fractional additional energy need.

do you think mitochondria notice the difference? I don't.

If I cut my caloric intake, I drop weight like nobody's business, and that's all thanks to my mitochondria at their place in the chain. It's the same thing my mitochondria are doing when I overeat and put on weight.

Seems like a potential use for peptides like Mots-C or SLU-PP-332

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