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hmontazeritoday at 4:50 AM6 repliesview on HN

Just do fasting and lose weight. Had high cholesterol and did that lost 20 pounds and my cholesterol went back to normal without any medical intervention


Replies

Kirby64today at 5:08 AM

I’m glad that worked for you. That doesn’t work for everyone, and there’s plenty of people with completely healthy weights who eat healthy as well who just have outrageous cholesterol. Any medical interventions that fix genetic conditions seem like a win for me. Even fixing lifestyle issues medically (eg GLP-1s) seem like a win for me.

ivankratoday at 5:06 AM

This is more about lp(a) type of cholesterol which is largely driven by genetics, and barely responds to lifestyle/diet.

lp(a) is not part of routine blood tests - you probably didn't measure it unless you specifically asked for it.

lurker_72today at 6:35 AM

I have familial hypercholesterolemia and none of that makes any difference. In fact 2 of my siblings and both my daughters have it too. My youngest sister had a stroke at 24 because of it.

Diet, statins, etc can't get us in healthy ranges and PCKS9 inhibitors is literally the only thing that moves the needle. I'm on Repatha, one of the injectable inhibitors, statins and Ezetimibe to manage it.

Needless to say I am super happy about this news, especially if it is affordable.

Really hopeful that Verve 102 passes trials and becomes generally available.

mikestewtoday at 5:28 AM

8% body fat, and I can run more in a day than most people do in a week. I’m taking statins. It’s not always as simple as you seem to assume. As others have said, genetics play role, for one.

dev_l1x_betoday at 5:45 AM

Are you seriously suggesting to cut into pharma profits?