alt Hacker NewsUsually, chronically-overweight ppl have tried regulating weight with all kinds of diets, lifecycle interventions, regular exercise, etc, and a lot of the time the thing that actually worked was the GLP-1. I think this speaks a lot to the variance in metabolism, hunger, cravings etc across the population.
The rub is that if they did a good job with those things, they would have worked. Most people cannot accurately account for calories and poorly estimate how hard they are actually working out.