From the article:

“He’d waffle between jittery agitation, as though he’d just had seven cups of coffee, and a fatigue so profound that he could hardly get off the living room couch.”

“I was convinced I’d come down with some severe condition that was going to kill me,” he says. For the next two years, Roes’s life became a series of waiting rooms and tests: blood work, brain scans, heart screenings. “I was having severe fevers and extreme phases where I would go into such a brain fog, I thought I might black out,” he says. The tests yielded no definitive diagnosis.

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I have lived this myself. I’m not an ultra runner but many of these symptoms These runners have I have without ever being into exercise. And it runs in my family. They keep finding little weird things in my test results, but it’s never anything that leads to a diagnosis or affect. They label me with a psychological disorder only.

I’m inclined to think that both my issue and these runners issues has to do with how they handle oxidative stress and the damage that can do to the neurological system. We know these runners are fueled by a sort of addiction to the running. And that’s going to involve dopamine. But since you have to metabolize dopamine using monoamine oxidize enzymes, you’re going to create hydrogen peroxide, and oxidative stressor, as a product. In my opinion to understand, neurological disorders, you need to understand how oxidative stress damages the neurons and the immune system.

And it seems by even just thinking about this I was right I just googled over training and oxidative stress and came up with this paper

https://pmc.ncbi.nlm.nih.gov/articles/PMC3435910/

The four theories of the disorder from the same magazine, which includes oxidated distress as one of them

https://www.outsideonline.com/health/training-performance/ov...

So I’m assuming the people this affects probably have some mild genetic issue that makes them a little bit worse at handling oxidative stress of some sort. This could be with glutathione peroxide or catalyze or any of the nutrients needed for us to absorb the cofactors that enable us to get rid of oxidative stress.